IMM events :
The Institut de Microbiologie de la Méditerranée (IMM) organises scientific seminars for researchers every Friday at 11.30am.
These seminars are announced in the Institute’s diary.
The seminar organising committee is made up of :
– Bénédicte BURLAT, researcher at BIP
– Isabelle IMBERT, teacher-researcher at LISM
– Vladimir PELICIC, researcher at the LCB
– Hugo BISIO, researcher at IGS
Seminar information :
– Frequency: Every Friday
– Time: 11.30 a.m.
– Accessibility: These events are not open to the general public. For open events, please consult the public events page.
List of Seminars:
Below is the list of scientific seminars scheduled for the coming month.
If you have any questions or require further information, please do not hesitate to contact the organising committee: seminaires@imm.cnrs.fr
- This event has passed.
Role of lipid gradients in membrane repair and osteogenesis
Joost Holthuis d’Osnabruck (Molecular Cell Biology Division, Department of Biology/Chemistry, Center for Cellular Nanoanalytics Osnabrück, University of Osnabrück, Germany)
Role of lipid gradients in membrane repair and osteogenesis
Sphingomyelin (SM) is a dominant sphingolipid in mammals. Its bulk production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a SM/cholesterol gradient along the secretory pathway. This gradient marks a fundamental transition in physical membrane properties that help specify organelle identity and function. We previously showed that plasma membrane (PM)-resident SM synthase SMS2 is highly expressed in bone and identified heterozygous mutations in the SMS2-coding gene as the underlying cause of a congenital form of skeletal dysplasia.
Strikingly, pathogenic SMS2 variants invariably disrupt the SM gradient along the secretory pathway, break SM asymmetry across cellular bilayers, and perturb cholesterol organization at the PM. In parallel, we uncovered Ca2+-activated SM scrambling and turnover as a novel mechanism to drive an inverse budding of cellular bilayers, a process implicated in bone mineralization and repair of damaged organelles. In this talk, I will discuss our current efforts to unravel the functional consequences of, and compensatory cellular responses to disease-induced perturbations in SM gradients.
Invited by Lucie Bergdoll (LISM)