IMM events :
The Institut de Microbiologie de la Méditerranée (IMM) organises scientific seminars for researchers every Friday at 11.30am.
These seminars are announced in the Institute’s diary.
The seminar organising committee is made up of :
– Bénédicte BURLAT, researcher at BIP
– Isabelle IMBERT, teacher-researcher at LISM
– Vladimir PELICIC, researcher at the LCB
– Hugo BISIO, researcher at IGS
Seminar information :
– Frequency: Every Friday
– Time: 11.30 a.m.
– Accessibility: These events are not open to the general public. For open events, please consult the public events page.
List of Seminars:
Below is the list of scientific seminars scheduled for the coming month.
If you have any questions or require further information, please do not hesitate to contact the organising committee: seminaires@imm.cnrs.fr
- This event has passed.
Igor B. Jouline (invited by Emilia Mauriello, LCB)
Igor B. Jouline (guest Emilia Mauriello, LCB), Department of Microbiology, The Ohio State University
“PAS and Cache: homologous small molecule binding sensors conserved from bacteria to humans”
PAS and Cache domains are two superfamilies of ubiquitous sensor domains that are found throughout the tree of life. PAS and Cache domains bind small molecules, either as ligands or cofactors and transmit information to downstream signaling domains. Both PAS and Cache domains are associated with a variety of signaling domains. In bacteria and archaea, they are found in histidine kinases, chemoreceptors, enzymes controlling second messenger turnover, etc. In eukaryotes, they are found in ion channels, serine/threonine kinases and phosphatases and other signaling proteins. PAS and Cache share the same overall structure (called PAS fold) and evolutionary origins, but they have distinct features reflecting their key differences. PAS domains are intracellular sensors and adopt a classical globular PAS fold. Cache domains are extracellular sensors and in addition to PAS fold their structure contains helical extensions of two transmembrane helices that anchor Cache-containing signaling proteins in the membrane.
I will show how by combining experimental and computational approaches we can confidently predict cofactors (such as heme, FAD, and FMN) and small molecules (such as amino acids, biogenic amines, and nucleotides) that are recognized by specific PAS and Cache family members ranging from bacteria to humans. Identification of bacterial homologs of human PAS and Cache domains provides an opportunity for efficient modeling in drug design.
References :
Gumerov VM et al (2022) Amino acid sensor conserved from bacteria to humans. PNAS 119: e2110415119.
Xing J _et a_l (2023) Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor. Sci Adv 9: eadi4517.
Cerna-Vargas JP et al (2023) Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor. PNAS 120: e2305837120.
Monteagudo-Cascales E et al (2024) Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria. Nat Commun 15: 5867