IMM events :
The Institut de Microbiologie de la Méditerranée (IMM) organises scientific seminars for researchers every Friday at 11.30am.
These seminars are announced in the Institute’s diary.
The seminar organising committee is made up of :
– Bénédicte BURLAT, researcher at BIP
– Isabelle IMBERT, teacher-researcher at LISM
– Vladimir PELICIC, researcher at the LCB
– Hugo BISIO, researcher at IGS
Seminar information :
– Frequency: Every Friday
– Time: 11.30 a.m.
– Accessibility: These events are not open to the general public. For open events, please consult the public events page.
List of Seminars:
Below is the list of scientific seminars scheduled for the coming month.
If you have any questions or require further information, please do not hesitate to contact the organising committee: seminaires@imm.cnrs.fr
- This event has passed.
Under Pressure: How Pathogens Sense and Respond to Host-Induced Stresses
Séverin Ronneau (Inserm, Rennes University)
Pathogenic bacteria require dedicated mechanisms to adapt to the complex and fluctuating conditions they encounter within the host. One of the most universal adaptation mechanisms is the stringent response, which relies on the rapid accumulation of the alarmone nucleotides (p)ppGpp. Despite its central role, how the stringent response detects and integrates host-induced stresses remains elusive. In this seminar, I will present new insights into how infection-relevant stresses—such as iron limitation and oxidative damage—modulate the stringent response in major Gram-negative pathogens, including Salmonella enterica, Enterobacter cloacae, and Klebsiella pneumoniae. I will also discuss how (p)ppGpp reprograms bacterial transcription to promote stress adaptation and enhance virulence within the host. Together, these findings highlight a conserved mechanism by which pathogenic bacteria integrate metabolic stress into adaptive gene regulation, linking environmental sensing to transcriptional control during infection.
Invited by Pierre Mandin (LCB).